Cyclosporin A-d4

• CAT Number: I042813
• Molecular Formula: C62H107D4N11O12
• Molecular Weight: 1206.64
• Purity: ≥95%
• Synonyms: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-ethyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-33-[(E,1R,2R)-5,6,6,6-tetradeuterio-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
• InChI: InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42-,43+,44+,45+,46+,47+,49+,50+,51+,52-/m1/s1/i1D3,25D
• InChIKey: PMATZTZNYRCHOR-XVPVDVKSSA-N
• SMILES: [2H]/C(=C\C[C@@H](C)[C@H]([C@H]1C(=O)N[C@H](C(=O)N(CC(=O)N([C@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C)CC)O)/C([2H])([2H])[2H]

Cyclosporin A-d4（Cat No.:I042813）is a deuterated form of cyclosporin A, a potent immunosuppressant used to prevent organ rejection following transplantation and to treat autoimmune diseases. The deuteration (replacing hydrogen atoms with deuterium) enhances its stability in metabolic studies, making it valuable for research purposes. Cyclosporin A-d4 is often used in pharmacokinetic studies, drug metabolism research, and to track the pharmacological effects of cyclosporin A in various biological systems. Its deuterated form allows for more precise measurements in mass spectrometry and other analytical techniques, aiding in the understanding of cyclosporin’s metabolic pathways.