Cyclosporine G

• CAT Number: I025397
• CAS Number: 74436-00-3
• Molecular Formula: C63H113N11O12
• Molecular Weight: 1216.66
• Purity: 98%
• Synonyms: Cyclosporine G; Geclosporin; 2-norVal-cyclosporin; Cyclosporin G
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: (3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-33-((1R,2R,E)-1-hydroxy-2-methylhex-4-en-1-yl)-6,9,18,24-tetraisobutyl-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecaone
• InChI: InChI=1S/C63H113N11O12/c1-25-27-29-41(15)53(76)52-57(80)66-44(28-26-2)59(82)68(18)34-49(75)69(19)45(30-35(3)4)56(79)67-50(39(11)12)62(85)70(20)46(31-36(5)6)55(78)64-42(16)54(77)65-43(17)58(81)71(21)47(32-37(7)8)60(83)72(22)48(33-38(9)10)61(84)73(23)51(40(13)14)63(86)74(52)24/h25,27,35-48,50-53,76H,26,28-34H2,1-24H3,(H,64,78)(H,65,77)(H,66,80)(H,67,79)/b27-25+/t41-,42+,43-,44+,45+,46+,47+,48+,50+,51+,52+,53-/m1/s1
• InChIKey: ZMKGDQSIRSGUDJ-VSROPUKISA-N
• SMILES: O=C([C@H](C(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@H](CC(C)C)N(C)C([C@@H](C)NC([C@H](C)NC([C@H](CC(C)C)N(C)C([C@H](C(C)C)NC([C@H](CC(C)C)N(C)C(CN(C)C([C@H](CCC)N1)=O)=O)=O)=O)=O)=O)=O)=O)=O)N(C)[C@@H]([C@H](O)[C@H](C)C/C=C/C)C1=O

Cyclosporine G(CAT: I025397) is a cyclic undecapeptide derived from fungal sources, known for its potent immunosuppressive properties. It functions by inhibiting calcineurin, a key enzyme in T-cell activation, thereby suppressing the immune response. Cyclosporine G is particularly valuable in immunology and transplant research, where it aids in preventing graft rejection and studying autoimmune disorders. Its mechanism of action makes it a critical tool for exploring T-cell-mediated immunity and developing therapies for conditions requiring immune modulation, such as organ transplantation and inflammatory diseases.