Cyclovirobuxine D

• CAT Number: R024216
• CAS Number: 860-79-7
• Molecular Formula: C26H46N2O
• Molecular Weight: 402.66
• Purity: ≥95%
• Synonyms: 4,4,14-Trimethyl-3β,20α-bis(methylamino)- 9,19-Cyclo-5α,9β-pregnan-16α-ol; ?1H,19H-Cyclopropa[9,10]cyclopenta[a]phenanthrene 9,19-Cyclopregnan-16-ol deriv.?(3α,5α,16α,20S)-4,4,14-Trimethyl-3,20-bis(methylamino)-9,19-cyclopregnan-16-ol?Bebuxine; CVB-D
• Target: Autophagy
• Storage: store at -20℃
• IUPAC Name: (1S,3R,6S,8R,11S,12S,14R,15S,16R)-7,7,12,16-tetramethyl-6-(methylamino)-15-[(1S)-1-(methylamino)ethyl]pentacyclo[9.7.0.01,3.03,8.012,16]octadecan-14-ol
• InChI: 1S/C26H46N2O/c1-16(27-6)21-17(29)14-24(5)19-9-8-18-22(2,3)20(28-7)10-11-25(18)15-26(19,25)13-12-23(21,24)4/h16-21,27-29H,8-15H2,1-7H3/t16-,17+,18-,19-,20-,21-,23+,24-,25+,26-/m0/s1
• InChIKey: GMNAPBAUIVITMI-ABNIRSKTSA-N
• SMILES: C[C@@H]([C@H]1[C@@H](C[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)NC)C)C)O)NC

Cyclovirobuxine D (Cat No.: R024216) is an active compound extracted from Buxus microphylla, which has been used for treating acute myocardial ischemia.Cyclovirobuxine D increases cardiomyocytes viability injured by oxidation or hypoxia. It significantly reduces the infarct size induced by ligating the coronary artery in rats. In addition, Cyclovirobuxine D protects rat aorta endothelial cells against hypoxia and enhanced nitric oxide (NO) release from endothelial cells.Cyclovirobuxine D decreases the weight of venous thrombus in rats.