For research use only. Not for therapeutic Use.
CYM-5541 is a selective, allosteric agonist of S1P3 (EC50 = 72-132 nM). Sphingosine 1-phosphate (S1P) is a lysophospholipid signaling molecule that regulates important biological functions, including lymphocyte trafficking and vascular development, by activating G protein-coupled receptors for S1P, namely, S1P(1) through S1P(5)
| Catalog Number | R061189 |
| CAS Number | 945128-26-7 |
| Synonyms | N,N-Dicyclohexyl-5-cyclopropyl-3-isoxazolecarboxamide, ML-249, CID-17253208 |
| Molecular Formula | C19H28N2O2 |
| Purity | ≥95% |
| Target | LPL Receptor |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at +4C |
| IUPAC Name | N,N-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide |
| InChI | InChI=1S/C19H28N2O2/c22-19(17-13-18(23-20-17)14-11-12-14)21(15-7-3-1-4-8-15)16-9-5-2-6-10-16/h13-16H,1-12H2 |
| InChIKey | NDKGACIWVAOUQH-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)N(C2CCCCC2)C(=O)C3=NOC(=C3)C4CC4 |
| Reference | </br>1: Jo E, Bhhatarai B, Repetto E, Guerrero M, Riley S, Brown SJ, Kohno Y, Roberts </br> E, Schürer SC, Rosen H. Novel selective allosteric and bitopic ligands for the</br> S1P(3) receptor. ACS Chem Biol. 2012 Dec 21;7(12):1975-83. doi:</br> 10.1021/cb300392z. PubMed PMID: 22971058; PubMed Central PMCID: PMC3528827.</br></br> |
