For research use only. Not for therapeutic Use.
CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1].
SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates[1].
| Catalog Number | R040887 |
| CAS Number | 1383478-94-1 |
| Synonyms | N-[4-(dimethylsulfamoyl)phenyl]-4-[hydroxy(diphenyl)methyl]piperidine-1-carbothioamide |
| Molecular Formula | C27H31N3O3S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H31N3O3S2/c1-29(2)35(32,33)25-15-13-24(14-16-25)28-26(34)30-19-17-23(18-20-30)27(31,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-16,23,31H,17-20H2,1-2H3,(H,28,34) |
| InChIKey | VAUKHARIAMDAGF-UHFFFAOYSA-N |
| SMILES | CN(C)S(=O)(=O)C1=CC=C(C=C1)NC(=S)N2CCC(CC2)C(C3=CC=CC=C3)(C4=CC=CC=C4)O |
| Reference | [1]. Mittapalli GK, et al. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3916-20. |
