For research use only. Not for therapeutic Use.
CYP4A11/CYP4F2-IN-1 is a potent dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50s of 19 nM and 17 nM, respectively. CYP4A11/CYP4F2-IN-1 has potential for the research of renal diseases[1].
CYP4A11/CYP4F2-IN-1 (compound 2) inhibits 20-Hydroxyeicosatetraenoic acid (20-HETE) production from arachidonic acid in human renal microsomes, with an IC50 of 4.2 nM[1].
| Catalog Number | I042578 |
| CAS Number | 502654-40-2 |
| Synonyms | 4-methyl-5-[2-[4-(1H-pyrazol-5-yl)phenoxy]ethyl]-1,3-thiazole |
| Molecular Formula | C15H15N3OS |
| Purity | ≥95% |
| InChI | InChI=1S/C15H15N3OS/c1-11-15(20-10-16-11)7-9-19-13-4-2-12(3-5-13)14-6-8-17-18-14/h2-6,8,10H,7,9H2,1H3,(H,17,18) |
| InChIKey | QVEFQEQVSXFMCV-UHFFFAOYSA-N |
| SMILES | CC1=C(SC=N1)CCOC2=CC=C(C=C2)C3=CC=NN3 |
| Reference | [1]. Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613. |
