For research use only. Not for therapeutic Use.
CypD-IN-29(CAT: I025425) is a potent and selective inhibitor of cyclophilin D (CypD), a critical regulator of the mitochondrial permeability transition pore (mPTP). By inhibiting CypD, this compound prevents mPTP opening, thereby protecting mitochondria from calcium overload and oxidative stress. CypD-IN-29 has been extensively studied for its potential to mitigate mitochondrial dysfunction, making it a valuable tool in research on neurodegenerative diseases, ischemia-reperfusion injury, and cardiovascular disorders. Its specificity for CypD supports the exploration of mitochondrial dynamics and the development of therapeutic strategies targeting mitochondrial integrity in various pathological conditions.
| CAS Number | 1115335-95-9 |
| Synonyms | CypDIN29; CypD IN 29; CypD-IN-29 |
| Molecular Formula | C26H20FN5O2S |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 3-(2-((2-((2-Cyanophenyl)amino)-2-oxoethyl)thio)-1H-imidazol-1-yl)-N-(4-fluorobenzyl)benzamide |
| InChI | InChI=1S/C26H20FN5O2S/c27-21-10-8-18(9-11-21)16-30-25(34)19-5-3-6-22(14-19)32-13-12-29-26(32)35-17-24(33)31-23-7-2-1-4-20(23)15-28/h1-14H,16-17H2,(H,30,34)(H,31,33) |
| InChIKey | WAPJUYVZASTWRM-UHFFFAOYSA-N |
| SMILES | O=C(NCC1=CC=C(F)C=C1)C2=CC=CC(N3C=CN=C3SCC(NC4=CC=CC=C4C#N)=O)=C2 |
