CyPPA

For research use only. Not for therapeutic Use.

  • CAT Number: R032740
  • CAS Number: 73029-73-9
  • Molecular Formula: C16H23N5
  • Molecular Weight: 285.39
  • Purity: ≥95%
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CyPPA is a positive modulator of hSK3 and hSK2, with EC50 values of 14 μM and 5.6 μM, repectively. CyPPA is inactive on both hSK1 and hIK channels[1][2].
CyPPA induces a concentration-dependent increase in the apparent Ca2+-sensitivity of channel activation, changing the EC50 (Ca2+) from 429 nM to 59 nM[1].
CyPPA, a positive modulator of small-conductance Ca2+-activated K+ channels, inhibits phasic uterine contractions and delays preterm birth in mice[2].


Catalog Number R032740
CAS Number 73029-73-9
Synonyms

N-cyclohexyl-2-(3,5-dimethylpyrazol-1-yl)-6-methylpyrimidin-4-amine

Molecular Formula C16H23N5
Purity ≥95%
InChI InChI=1S/C16H23N5/c1-11-10-15(18-14-7-5-4-6-8-14)19-16(17-11)21-13(3)9-12(2)20-21/h9-10,14H,4-8H2,1-3H3,(H,17,18,19)
InChIKey USEMRPYUFJNFQN-UHFFFAOYSA-N
SMILES CC1=CC(=NC(=N1)N2C(=CC(=N2)C)C)NC3CCCCC3
Reference

[1]. Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate. Br J Pharmacol. 2007 Jul;151(5):655-65.
 [Content Brief]

[2]. Dana V Skarra, et al. CyPPA, a positive modulator of small-conductance Ca(2+)-activated K(+) channels, inhibits phasic uterine contractions and delays preterm birth in mice. Am J Physiol Cell Physiol. 2011 Nov;301(5):C1027-35.
 [Content Brief]

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