Cys modifier 1

• CAT Number: I019225
• CAS Number: 2374314-08-4
• Molecular Formula: C18H15N5O5
• Molecular Weight: 381.34
• Purity: ≥95%
• Synonyms: (E)-N-[2-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]ethyl]-4-oxo-4-phenylbut-2-enamide
• InChI: InChI=1S/C18H15N5O5/c24-15(12-4-2-1-3-5-12)8-9-16(25)20-11-10-19-13-6-7-14(23(26)27)18-17(13)21-28-22-18/h1-9,19H,10-11H2,(H,20,25)/b9-8+
• InChIKey: BCMZWBOLYVJVMB-CMDGGOBGSA-N
• SMILES: C1=CC=C(C=C1)C(=O)C=CC(=O)NCCNC2=CC=C(C3=NON=C23)[N+](=O)[O-]

Cys modifier 1 (compound 7) is a cysteine-selective protein modifier for protein bioconjugation. A fluorescent carbonylacrylic derivative bearing nitrobenzofurazan (λex=465nm and λem539 nm)[1].

Reference

[1]. Bernardim B, et al. Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents. Nat Commun. 2016 Oct 26;7:13128.
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