For research use only. Not for therapeutic Use.
Cytarabine is an antimetabolic agent and DNA synthesis inhibitor with IC50 of 16 nM in wild-type CCRF-CEM cells.<br>Cytarabine (AraC) is phosphorylated into a triphosphate form (Ara-CTP) involving deoxycytidine kinase (dCK), which competes with dCTP for incorporation into DNA, and then blocks DNA synthesis by inhibiting the function of DNA and RNA polymerases. Cytarabine displays a higher growth inhibitory activity towards wild-type CCRF-CEM cells compared to other acute myelogenous leukemia (AML) cells with IC50 of 16 nM.<br>Cytarabine is highly effective against acute leukaemias, which causes the characteristic G1/S blockage and synchronization, and increases the survival time for leukaemic Brown Norway rats in a weak dose-related fashion indicating that the use of higher dosages of Cytarabine does not contribute to its antileukaemic effectiveness in man.
| Catalog Number | A000876 |
| CAS Number | 147-94-4 |
| Synonyms | NA |
| Molecular Formula | C9H13N3O5 |
| Purity | ≥95% |
| Target | DNA Synthesis |
| Solubility | Limited solubility |
| Storage | 3 years -20C powder |
| InChIKey | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
