Cytarabine hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: I004619
  • CAS Number: 69-74-9
  • Molecular Formula: C9H14ClN3O5
  • Molecular Weight: 279.68
  • Purity: ≥95%
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Cytarabine hydrochloride (CAT: I004619), also known as cytosine arabinoside or Ara-C, is a chemotherapy medication used in the treatment of various types of cancer, particularly leukemia. It is a nucleoside analog that inhibits DNA synthesis by incorporating into DNA strands and interfering with their replication. Cytarabine is primarily used in the treatment of acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and certain types of lymphoma. It may be administered intravenously or subcutaneously, depending on the specific treatment regimen. Cytarabine can cause various side effects, including myelosuppression, gastrointestinal disturbances, and neurotoxicity. Close monitoring and proper supportive care are important during treatment with cytarabine.


Catalog Number I004619
CAS Number 69-74-9
Synonyms

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride

Molecular Formula C9H14ClN3O5
Purity ≥95%
Target DNA Synthesis
Solubility 10 mM in DMSO
Storage Store at -20C
Reference

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<br>[1]. Tobias, S.C. and R.F. Borch, Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm, 2004. 1(2): p. 112-6.
<br>[2]. Besirli, C.G., et al., Cytosine arabinoside rapidly activates Bax-dependent apoptosis and a delayed Bax-independent death pathway in sympathetic neurons. Cell Death Differ, 2003. 10(9): p. 1045-58.
<br>[3]. Yamauchi, H., et al., Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta. Biol Reprod, 2004. 70(6): p. 1762-7.
<br>[4]. Richel, D.J., et al., Comparison of the antileukaemic activity of 5 aza-2-deoxycytidine and arabinofuranosyl-cytosine in rats with myelocytic leukaemia. Br J Cancer, 1988. 58(6): p. 730-3.
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