Cytidine 5/'-triphosphate (sodium salt)

• CAT Number: R065718
• CAS Number: 36051-68-0
• Molecular Formula: C9H14N3O14P3 • 2Na
• Molecular Weight: 527.1
• Purity: ≥95%
• Synonyms: CTP;NSC 20261
• Target: Endogenous Metabolite
• Storage: -20°C
• InChI: InChI=1S/C9H16N3O14P3.2Na/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18);;/q;2*+1/p-2/t4-,6-,7-,8-;;/m1../s1
• InChIKey: NFQMDTRPCFJJND-WFIJOQBCSA-L
• SMILES: O=P(OP(OP(O)([O-])=O)([O-])=O)(O)OC[C@H]1O[C@@H](N2C(N=C(N)C=C2)=O)[C@H](O)[C@@H]1O.[Na+].[Na+]

Cytidine 5/’-triphosphate (CTP) is a pyrimidine nucleoside triphosphate that is involved in a variety of biochemical reactions. It is used in the synthesis of RNA by RNA polymerases. In the formation of phosphatidylcholine (PC), CTP reacts with phosphocholine, via CTP:phosphocholine cytidylyltransferases, to produce CDP-choline and diphosphate. This is the rate-limiting step in PC synthesis and, as a pivotal step in cell proliferation, can be important in cancer. CTP also interacts with N-acylneuraminate, in a reaction mediated by N-acylneuraminate cytidylyltransferase, to generate an intermediate that is required for sialylation, namely CMP-N-acylneuraminic acid.

Reference

1.Li, Z. and Vance, D.E. Phosphatidylcholine and choline homeostasis. Journal of Lipid Research 49, 1187-1194 (2008).