Cytochalasin D

• CAT Number: R017488
• CAS Number: 22144-77-0
• PubChem Substance ID: 5458428
• Molecular Formula: C₃₀H₃₇NO₆
• Molecular Weight: 507.61
• Purity: 95%
• Synonyms: (3S,3aR,4S,6S,6aR,7E,10S,12R,13E,15R,15aR)-15-(Acetyloxy)-3,3a,4,5,6,6a,9,10,12,15-decahydro-6,12-dihydroxy-4,10,12-trimethyl-5-methylene-3-(phenylmethyl)-1H-cycloundec[d]isoindole-1,11(2H)-dione; (7S,13E,16S,18R,19E,21R)-[11]21-(Acetyloxy)-7,18-dihy
• Target: Actin
• Solubility: Soluble in DMSO > 10 mM
• Appearance: Grey solid
• Storage: Desiccate at -20C
• IUPAC Name: [(1R,2R,3E,5R,7S,9E,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-6,18-dioxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate
• InChI: InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
• InChIKey: CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O

Cytochalasin D(CAT: R017488) is a potent fungal metabolite that disrupts actin filament formation in eukaryotic cells. By binding to the barbed ends of actin filaments, Cytochalasin D prevents polymerization and elongation of the actin cytoskeleton. This disruption affects various cellular processes, including cell division, motility, and intracellular transport. It is widely used in research to study cell morphology, cytoskeletal dynamics, and related pathways such as apoptosis and cell migration. Cytochalasin D has been particularly valuable in cancer research and cell biology for understanding cytoskeletal functions and their role in disease mechanisms.