CZC-25146

• CAT Number: I000694
• CAS Number: 1191911-26-8
• Molecular Formula: C22H25FN6O4S
• Molecular Weight: 488.5
• Purity: ≥95%
• Synonyms: (E)-N-(2-((5-fluoro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4(3H)-ylidene)amino)phenyl)methanesulfonamide
• Target: LRRK2
• Solubility: DMSO: ≥ 46 mg/mL
• Storage: 2-8°C
• IC50: 4.76 nM/6.87 nM(wild type/G2019S LRRK2)
• IUPAC Name: N-[2-[[5-fluoro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
• InChI: InChI=1S/C22H25FN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)
• InChIKey: XXHHOTZUJIXPJX-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)F

CZC-25146 (Cat No.: I000694) is a potent and highly selective inhibitor of LRRK2 (Leucine-rich repeat kinase 2). It exhibits an impressive inhibitory activity, with IC50 values of 4.76 nM for human wild-type LRRK2 and 6.87 nM for G2019S mutant LRRK2. The selectivity of CZC-25146 for LRRK2 makes it a valuable tool in research related to this kinase, particularly in the study of its role in Parkinson’s disease and other neurodegenerative disorders. If you need to, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson/’s disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.