CZC-54252 hydrochloride

• CAT Number: I000695
• CAS Number: 1191911-27-9
• Molecular Formula: C₂₂H₂₅ClN₆O₄S.HCl
• Molecular Weight: 541.45
• Purity: ≥95%
• Synonyms: (E)-N-(2-((5-chloro-2-((2-methoxy-4-morpholinophenyl)amino)pyrimidin-4(3H)-ylidene)amino)phenyl)methanesulfonamide hydrochloride
• Target: LRRK2
• Solubility: 100 mM in DMSO
• Storage: -20°C
• IC50: 1.28 nM/1.85 nM(LRRK2/G2019S LRRK2)
• IUPAC Name: N-[2-[[5-chloro-2-(2-methoxy-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]phenyl]methanesulfonamide
• InChI: InChI=1S/C22H25ClN6O4S/c1-32-20-13-15(29-9-11-33-12-10-29)7-8-19(20)26-22-24-14-16(23)21(27-22)25-17-5-3-4-6-18(17)28-34(2,30)31/h3-8,13-14,28H,9-12H2,1-2H3,(H2,24,25,26,27)
• InChIKey: CLGWUCNXOBLWFM-UHFFFAOYSA-N
• SMILES: COC1=C(C=CC(=C1)N2CCOCC2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NS(=O)(=O)C)Cl

CZC-54252（Cat No.:I000695） is a potent LRRK2 inhibitor with IC50 of 1.28 nM and 1.85 nM for human wild-type LRRK2 and G2019S LRRK2, respectively. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.

Reference

[1]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson/’s disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.
[2]. Ramsden N, et al. Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson/’s disease-related toxicity in human neurons. ACS Chem Biol. 2011 Oct 21;6(10):1021-8.