For research use only. Not for therapeutic Use.
Highly potent and selective PI3K inhibitor, selectively inhibiting class I PI3K (PI3Kα IC50 <10 nM, >3 log selectivity against tyrosine or serine/threonine kinases, except ERK1 and 2) and showed some activity in A549 (lung cancer) xenografts mouse model at oral dose of 30 mg/kg twice daily
| Catalog Number | I047555 |
| CAS Number | 938444-93-0 |
| Molecular Formula | C17H18N6O |
| Purity | ≥95% |
| IUPAC Name | 1-ethyl-3-[3-(4-methylanilino)pyrido[2,3-b]pyrazin-6-yl]urea |
| InChI | InChI=1S/C17H18N6O/c1-3-18-17(24)23-14-9-8-13-16(21-14)22-15(10-19-13)20-12-6-4-11(2)5-7-12/h4-10H,3H2,1-2H3,(H3,18,20,21,22,23,24) |
| SMILES | CCNC(=O)NC1=NC2=NC(=CN=C2C=C1)NC3=CC=C(C=C3)C |
| Reference | SM Maira et al. Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway. Future Med. Chem. 2009, 1(1), 137-155. |
