D-64131

• CAT Number: I004769
• CAS Number: 74588-78-6
• Molecular Formula: C₁₆H₁₃NO₂
• Molecular Weight: 251.28
• Purity: ≥95%
• Synonyms: (5-methoxy-1H-indol-2-yl)(phenyl)methanone
• Target: Microtubule/Tubulin
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: N/A
• InChI: InChI=1S/C16H13NO2/c1-19-13-7-8-14-12(9-13)10-15(17-14)16(18)11-5-3-2-4-6-11/h2-10,17H,1H3
• InChIKey: ICMIJSRDISNKOC-UHFFFAOYSA-N
• SMILES: COC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3

D-64131 (CAT: I004769) is a novel inhibitor of tubulin polymerization, acting by competitively binding with [(3)H]colchicine to the αβ-tubulin subunits. By disrupting the polymerization of tubulin, which is crucial for microtubule formation and stability, D-64131 interferes with essential cellular processes that rely on intact microtubule networks. This inhibition can impact cell division, intracellular transport, and other functions that rely on microtubules.

Reference

[1]. Mahboobi, Siavosh; Pongratz, Herwig; Hufsky, Harald et al. Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents. Journal of Medicinal Chemistry (2001), 44(26), 4535-4553.
[2]. Bacher, G.; Beckers, T.; Emig, P. et al. New small-molecule tubulin inhibitors. Pure and Applied Chemistry (2001), 73(9), 1459-1464.
[3]. Beckers, Thomas; Reissmann, Thomas; Schmidt, Mathias et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119.