For research use only. Not for therapeutic Use.
D-Ala-D-Ala constitutes the terminus of the peptide part of the peptidoglycan monomer unit and is involved in the transpeptidation reaction as the substrate. D-Ala-D-Ala is catalyzed by D-Alanine-D-Alanine ligase. D-Ala-D-Ala is a bacterial endogenous metabolite[1][2].
| Catalog Number | I043246 |
| CAS Number | 923-16-0 |
| Synonyms | (2R)-2-[[(2R)-2-aminopropanoyl]amino]propanoic acid |
| Molecular Formula | C6H12N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H12N2O3/c1-3(7)5(9)8-4(2)6(10)11/h3-4H,7H2,1-2H3,(H,8,9)(H,10,11)/t3-,4-/m1/s1 |
| InChIKey | DEFJQIDDEAULHB-QWWZWVQMSA-N |
| SMILES | CC(C(=O)NC(C)C(=O)O)N |
| Reference | [1]. Kitamura Y, et al. Structure of D-alanine-D-alanine ligase from Thermus thermophilus HB8: cumulative conformational change and enzyme-ligand interactions. Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1098-106. [2]. Tytgat I, et al. DD-ligases as a potential target for antibiotics: past, present and future. Curr Med Chem. 2009;16(20):2566-80. |
