D-AP4

• CAT Number: I000531
• CAS Number: 78739-01-2
• Molecular Formula: C4H10NO5P
• Molecular Weight: 183.10
• Purity: ≥95%
• Synonyms: D-(-)-2-Amino-4-phosphonobutyric acid
• Target: Neuronal Signaling
• Solubility: Soluble to 100 mM in 1eq. NaOH
• Storage: Store at RT
• IUPAC Name: (2R)-2-amino-4-phosphonobutanoic acid
• InChI: InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m1/s1
• InChIKey: DDOQBQRIEWHWBT-GSVOUGTGSA-N
• SMILES: C(CP(=O)(O)O)[C@H](C(=O)O)N

D-AP4 (Cat No.:I000531) is a selective agonist for the metabotropic glutamate receptor subtype mGluR2, a G-protein-coupled receptor involved in the modulation of neurotransmission. By activating mGluR2, D-AP4 inhibits the release of glutamate, a major excitatory neurotransmitter, thereby playing a role in reducing excitotoxicity and modulating synaptic plasticity. D-AP4 has been used in research to explore the therapeutic potential of modulating glutamate signaling in neurological conditions, such as epilepsy, neurodegenerative diseases, and anxiety disorders. Its precise pharmacological effects and clinical applications are still being investigated in preclinical studies.