d-Atabrine dihydrochloride

• CAT Number: I020332
• CAS Number: 56100-41-5
• Molecular Formula: C₂₃H₃₂Cl₃N₃O
• Molecular Weight: 472.88
• Purity: ≥95%
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: (4S)-4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine;dihydrochloride
• InChI: InChI=1S/C23H30ClN3O.2ClH/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23;;/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26);2*1H/t16-;;/m0../s1
• InChIKey: UDKVBVICMUEIKS-SQKCAUCHSA-N
• SMILES: CCN(CC)CCC[C@H](C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC.Cl.Cl

d-Atabrine Dihydrochloride（Cat No.:I020332）, also known as quinacrine dihydrochloride, is a synthetic antimalarial agent with broad-spectrum activity against malaria parasites. Initially developed to combat malaria, it inhibits DNA and RNA synthesis, disrupting parasite replication. Beyond malaria, d-Atabrine Dihydrochloride has been explored for use in autoimmune disorders, such as lupus, and as an anti-protozoal for giardiasis. It has also shown potential in cancer research for its anticancer properties. Though largely replaced by newer antimalarials, it remains a valuable compound in pharmaceutical research for its diverse biological applications.

Reference

[1]. Ryou C, et al. Differential inhibition of prion propagation by enantiomers of quinacrine. Lab Invest. 2003 Jun;83(6):837-43.