For research use only. Not for therapeutic Use.
| Catalog Number | R020732 |
| CAS Number | 119567-63-4 |
| Synonyms | 2-Dimethylamino-4-octadecene-1,3-diol; D-erythro-N,N-Dimethylsphingosine; |
| Molecular Formula | C20H41NO2 |
| Purity | ≥95% |
| Target | SphK |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Store at -20C |
| InChIKey | YRXOQXUDKDCXME-YIVRLKKSSA-N |
| Reference | <br>1. J. Kim et al. “Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases” Bioorg Med Chem, Vol. 13 pp. 3475-3485, 2005<br>2. Y. Igarashi et al. “A Specific Enhancing Effect of N,N-Dimethylsphingosine on Epidermal Growth Factor Receptor Autophosphorylation” Journal ofBiological Chemistry, Vol. 265(10) pp. 5385-5389, 1990<br>3. Z. Jin and J. Karliner “Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKC? dependentmechanism” Journal of Cardiovascular Research, Vol. 71(4)pp. 725-734, 2006<br>4. R. McDonald et al. “The sphingosine kinase inhibitor N,N-dimethylsphingosine inhibits neointimal hyperplasia” British Journal of Pharmacology, Vol.159(3) pp. 543-553, 2010</br></br></br></br> |
