For research use only. Not for therapeutic Use.
D-erythro-sphingosine-1-phosphate (Cat No.:R000425) is a bioactive lipid molecule involved in numerous cellular processes, including cell proliferation, survival, migration, and immune responses. It acts as a ligand for a family of G-protein-coupled receptors known as S1P receptors, which are widely expressed in various tissues and play critical roles in development and homeostasis. S1P signaling is implicated in diverse physiological and pathological conditions, including cancer, cardiovascular diseases, and immune disorders. Modulating S1P signaling, either by targeting S1P receptors or altering S1P levels, has emerged as a potential therapeutic strategy for treating these diseases.
| Catalog Number | R000425 |
| CAS Number | 26993-30-6 |
| Synonyms | (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-(Dihydrogen phosphate); Sphingosine-1-phosphate; SPN-1-P; S1P. |
| Molecular Formula | C18H38NO5P |
| Purity | ≥95% |
| Target | GPCR/G Protein |
| Solubility | soluble in methanol |
| Storage | Desiccate at +4C |
| IUPAC Name | [(E,2S,3R)-2-amino-3-hydroxyoctadec-4-enyl] dihydrogen phosphate |
| InChI | InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1 |
| InChIKey | DUYSYHSSBDVJSM-KRWOKUGFSA-N |
| SMILES | CCCCCCCCCCCCCC=CC(C(COP(=O)(O)O)N)O |
| Reference | <br>1. M. Maceyka, S. Milstien, and S. Spiegel “Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling” Journal of Lipid Research, Vol. 50pp. S272-S276, 2009<br>2. S. Alvarez, S. Milstien, S. Spiegel “Autocrine and paracrine roles of sphingosine-1-phosphate” Trends Endocrinol. Metab., Vol. 18 pp. 300-307, 2007<br>3. J. Nofer “High-density lipoprotein, sphingosine-1-phosphate, and atherosclerosis” J. Clin. Lipidology, Vol. 2 pp. 4-11, 2008</br></br></br> |
