For research use only. Not for therapeutic Use.
D-Glucosamine-2-sulfate, a sulfate derivative of glucosamine, is derived from chitin and has anti-inflammatory effects. <em>In vitro</em>, it reduces expression of inflammatory markers, including IL-1β, COX-2, IL-6, and TNF-α in IL-1β-activated human chondrosarcoma SW1353 cells at a minimum effective concentration of 1 μM. At the same concentration, it limits expression of matrix metalloproteinase-3 (MMP-3) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5), both markers of matrix degradation. Treating human primary chondrocytes with D-glucosamine-2-sulfate stimulates proteoglycan production at a dose of 10 μg/mL and adhesion to fibronectin at a concentration of 50 μM.,
CAS Number | 38899-05-7 |
Synonyms | GlcN-2S |
Molecular Formula | C6H12NO8S • Na |
Purity | ≥95% |
Target | Endogenous Metabolite |
Storage | -20°C |
InChI | InChI=1S/C6H13NO8S.Na/c8-1-3(7-16(13,14)15)5(11)6(12)4(10)2-9;/h1,3-7,9-12H,2H2,(H,13,14,15);/q;+1/p-1/t3-,4+,5+,6+;/m0./s1 |
InChIKey | XEWPDPAXIJXJBU-BTVCFUMJSA-M |
SMILES | O[C@@H]([C@H](O)[C@H](O)CO)[C@@H](NS([O-])(=O)=O)C=O.[Na+] |
Reference | 1.Chiusaroli, R.,Piepoli, T.,Zanelli, T., et al. Experimental pharmacology of glucosamine sulfate. Int. J. Rheumatol. 939265 (2011). |