D-myo-Inositol-1,2,3,6-tetraphosphate (sodium salt)

• CAT Number: R023429
• Molecular Formula: C6H12O18P4 · 4Na
• Molecular Weight: 588
• Purity: ≥95%
• Synonyms: Ins(1,2,3,6)-P4 (sodium salt);1,2,3,6-IP4 (sodium salt)
• Storage: -20°C
• InChI: InChI=1S/C6H16O18P4.4Na/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11;;;;/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);;;;/q;4*+1/p-4/t1-,2-,3?,4?,5?,6?;;;;/m0..../s1
• InChIKey: DZJJWPAQUIBBLR-CZKBEOFPSA-J
• SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@H]1O.[Na+].[Na+].[Na+].[Na+]

D-<wbr></wbr>myo-<wbr></wbr>Inositol-<wbr></wbr>1,2,3,6-<wbr></wbr>tetraphosphate (Ins(1,2,3,6)-<wbr></wbr>P4) is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)-<wbr></wbr>P3 is a second messenger produced in cells by phospholipase C (PLC)-<wbr></wbr>mediated hydrolysis of phosphatidylinositol-<wbr></wbr>4,5-<wbr></wbr>biphosphate. Binding of Ins(1,4,5)-<wbr></wbr>P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(1,2,3,6)-<wbr></wbr>P3 (tested as the meso compound) is 100-<wbr></wbr>fold less potent than Ins(1,4,5)-<wbr></wbr>P3 at initiating Ca

Reference

1.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993).