D-myo-Inositol-1,3,4-triphosphate (sodium salt)

• CAT Number: R067323
• Molecular Formula: C6H12O15P3 • 3Na
• Molecular Weight: 486
• Purity: ≥95%
• Synonyms: Ins(1,3,4)-P3 (sodium salt);1,3,4-IP3 (sodium salt)
• Storage: -20°C
• InChI: InChI=1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3+,4?,5?,6?;;;/m1.../s1
• InChIKey: ZVCVTWVBDIPWPZ-WWKACLBASA-K
• SMILES: O[C@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](O)[C@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+]

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals. D-<wbr></wbr>myo-<wbr></wbr>Inositol-<wbr></wbr>1,3,4-<wbr></wbr>triphosphate (Ins(1,3,4)-<wbr></wbr>P3) is one of several different inositol oligophosphate isomers implicated in signal transduction. Ins(1,3,4)-<wbr></wbr>P3 acts through the inhibition of Ins(3,4,5,6)-<wbr></wbr>P4 kinase activity to increase the cellular level of Ins(3,4,5,6)-<wbr></wbr>P4 and thus inhibit calcium-<wbr></wbr>activated chloride channels. The levels of Ins(1,3,4)-<wbr></wbr>P3 are in turn regulated by the levels of cytosolic free calcium. The receptor-<wbr></wbr>mediated activation of phospholipase C (PLC) can be seen as the initiating event in this cascade, since PLC generates Ins(1,4,5)-<wbr></wbr>P3 which releases calcium from intracellular storage reservoirs, leading to a dramatic but transient increase in the cytosolic concentration of free calcium.

Reference

1.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993).