D-myo-Inositol-1,5-diphosphate (sodium salt)

• CAT Number: R023016
• Molecular Formula: C6H12O12P2 · 2Na
• Molecular Weight: 384.1
• Purity: ≥95%
• Synonyms: Ins(1,5)-P2 (sodium salt);1,5-IP2 (sodium salt)
• Storage: -20°C
• InChI: InChI=1S/C6H14O12P2.2Na/c7-1-2(8)5(17-19(11,12)13)4(10)6(3(1)9)18-20(14,15)16;;/h1-10H,(H2,11,12,13)(H2,14,15,16);;/q;2*+1/p-2/t1-,2-,3-,4-,5?,6?;;/m1../s1
• InChIKey: QGQLGMXVAUVPIQ-QPEFWZSESA-L
• SMILES: O[C@@H]1[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](O)[C@@H](O)[C@H]1OP([O-])(O)=O.[Na+].[Na+]

D-<wbr></wbr>myo-<wbr></wbr>Inositol-<wbr></wbr>1,5-<wbr></wbr>phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P3 is a second messenger produced in cells by phospholipase C (PLC)-<wbr></wbr>mediated hydrolysis of phosphatidyl inositol-<wbr></wbr>4,5-<wbr></wbr>biphosphate. Binding of Ins(1,4,5)P3 to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium.

Reference

1.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993).