For research use only. Not for therapeutic Use.
D-<wbr></wbr><em>myo</em>-<wbr></wbr>Inositol-<wbr></wbr>2,3,5-<wbr></wbr>triphosphate (ammonium salt) (Ins(2,3,5)P<sub>3</sub> (ammonium salt)) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals. The most studied InsP, Ins(1,4,5)P<sub>3</sub> is a second messenger produced in cells by phospholipase C (PLC)-<wbr></wbr>mediated hydrolysis of phosphatidylinositol-<wbr></wbr>4,5-<wbr></wbr>biphosphate. Binding Ins(1,4,5)P<sub>3</sub> to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,3,5)P<sub>3</sub> (ammonium salt) (tested as a racemic mixture) is 500-<wbr></wbr>fold less potent than Ins(1,4,5)-<wbr></wbr>P<sub>3</sub> at initiating Ca
| Catalog Number | R022465 |
| Synonyms | Ins(2,3,5)P3 (ammonium salt);2,3,5-IP3 (ammonium salt) |
| Molecular Formula | C6H12O15P3 · 3NH4 |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C6H15O15P3/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/p-3/t1-,2-,3-,4?,5?,6?/m0/s1 |
| InChIKey | MMWCIQZXVOZEGG-PIWFKJEKSA-K |
| SMILES | O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1OP([O-])(O)=O.[NH4+].[NH4+].[NH4+] |
| Reference | 1.Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361, 315-325 (1993). |
