For research use only. Not for therapeutic Use.
The inositol phosphates (InsP) play a critical role as small, soluble second messengers in the transmission of cellular signals. The most studied InsP, D-<wbr></wbr><em>myo</em>-<wbr></wbr>Inositol-<wbr></wbr>2,4,5-<wbr></wbr>triphosphate (sodium salt) (Ins(1,4,5)P<sub>3</sub>), more commonly referred to as IP<sub>3</sub>, is a second messenger produced in cells by phospholipase C (PLC)-<wbr></wbr>mediated hydrolysis of phosphatidylinositol-<wbr></wbr>4,5-<wbr></wbr>biphosphate. Binding of Ins(1,4,5)P<sub>3</sub> to its receptor on the endoplasmic reticulum results in opening of the calcium channels and an increase in intracellular calcium. Ins(2,4,5)P<sub>3</sub> is a metabolically stable analog of Ins(1,4,5)P<sub>3</sub> that is commonly used to study Ca
| Catalog Number | R018455 |
| Synonyms | Ins(2,4,5)P3 (sodium salt);2,4,5-IP3 (sodium salt) |
| Molecular Formula | C6H12O15P3 · 3Na |
| Purity | ≥95% |
| Storage | -20°C |
| InChI | InChI=1S/C6H15O15P3.3Na/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2-,3-,4?,5?,6?;;;/m0.../s1 |
| InChIKey | ZVCVTWVBDIPWPZ-UIEDNGEDSA-K |
| SMILES | O[C@H]1[C@H](O)[C@@H](OP([O-])(O)=O)[C@H](OP([O-])(O)=O)[C@@H](O)[C@H]1OP([O-])(O)=O.[Na+].[Na+].[Na+] |
| Reference | 1.Majerus, P.W. Inositol phosphate biochemistry. Annual Reviews of Biochemistry 61, 225-250 (1992). |
