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-[D-p-Cl-Phe6,Leu17]-VIP TFA [D-p-Cl-Phe6,Leu17]-VIP TFA

[D-p-Cl-Phe6,Leu17]-VIP TFA

For research use only. Not for therapeutic Use.

  • CAT Number: I045805
  • Molecular Formula: C150H240F3ClN44O44
  • Molecular Weight: 3456.22
  • Purity: ≥95%
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Related Small Molecules: 1beta-Hydroxyalantolactone     ALV2     1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine    

[D-p-Cl-Phe6,Leu17]-VIP TFA is a competitive and selective antagonist of vasoactive intestinal peptide (VIP) receptor, with the IC50 of 125.8 nM. [D-p-Cl-Phe6,Leu17]-VIP TFA has no activity on glucagon, secretin or GRF receptors[1][2][3].


Catalog Number I045805
Molecular Formula C150H240F3ClN44O44
Purity ≥95%
Reference

[1]. Pozo D, et, al. Characterization of VIP receptor-effector system antagonists in rat and mouse peritoneal macrophages. Eur J Pharmacol. 1997 Mar 5; 321(3): 379-86.
 [Content Brief]

[2]. Pandol SJ, et, al. Vasoactive intestinal peptide receptor antagonist [4Cl-D-Phe6, Leu17] VIP. Am J Physiol. 1986 Apr; 250 (4 Pt 1): G553-7.
 [Content Brief]

[3]. Messmer B, et, al. Regulation of exocrine pancreatic secretion by cerebral TRH and CGRP: role of VIP, muscarinic, and adrenergic pathways. Am J Physiol. 1993 Feb; 264(2 Pt 1): G237-42.
 [Content Brief]

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