For research use only. Not for therapeutic Use.
Phytosphingosine（Cat No.:R013870） is a bioactive phospholipid known for its anticancer effects. In cancer cells, it plays a vital role in inducing apoptosis, a process of programmed cell death. Phytosphingosine achieves this by activating caspase 8, an enzyme involved in apoptotic pathways, and promoting the translocation of Bax, a pro-apoptotic protein, within the cells. These mechanisms lead to the selective elimination of cancer cells, making Phytosphingosine a promising candidate for cancer therapy research.
| Catalog Number | R013870 |
| CAS Number | 554-62-1 |
| Synonyms | (2S,3S,4R)-2-Amino-1,3,4-octadecanetriol; Phytosphingosine; (+)-D-ribo-Phytosphingosine; 4-D-Hydroxysphinganine; 4D-Hydroxysphinganine; C18-Phytosphingosine; D-ribo-1,3,4-Trihydroxy-2-aminooctadecane; |
| Molecular Formula | C18H39NO3 |
| Purity | ≥95% |
| Target | Metabolic Enzyme/Protease |
| Storage | −20°C |
| IUPAC Name | (2S,3S,4R)-2-aminooctadecane-1,3,4-triol |
| InChI | InChI=1S/C18H39NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20/h16-18,20-22H,2-15,19H2,1H3/t16-,17+,18-/m0/s1 |
| InChIKey | AERBNCYCJBRYDG-KSZLIROESA-N |
| SMILES | CCCCCCCCCCCCCCC(C(C(CO)N)O)O |
| Reference | <br>1. K. Liu et al. “The Sphingoid Long Chain Base Phytosphingosine Activates AGC-type Protein Kinases in Saccharomyces cerevisiae Including Ypk1,Ypk2, and Sch9” Journal of Biological Chemistry, Vol. 280(24) pp. 22679, 2005<br>2. K. Ryu et al. “Anti-scratching Behavioral Effects of N-Stearoylphytosphingosine and 4-Hydroxysphinganine in Mice” Lipids, Vol. 45 pp. 615-618, 2010<br>3. M. Park et al. “Suppression of Extracellular Signal-related Kinase and Activation of p38 MAPK Are Two Critical Events Leading to Caspase-8- andMitochondria-mediated Cell Death in Phytosphingosine-treated Human Cancer Cells” Journal of Biological Chemistry, Vol. 278, pp. 50624-50634, 2003<br>4. N. Chung et al. “Phytosphingosine as a Specific Inhibitor of Growth and Nutrient Import in Saccharomyces cerevisiae” Journal of Biological Chemistry,Vol. 276 pp. 35614-35621, 2001</br></br></br></br> |
