For research use only. Not for therapeutic Use.
D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1].
| Catalog Number | I019012 |
| CAS Number | 662164-09-2 |
| Synonyms | N-(1-phenylethyl)-2-piperazin-1-ylquinazolin-4-amine |
| Molecular Formula | C20H23N5 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H23N5/c1-15(16-7-3-2-4-8-16)22-19-17-9-5-6-10-18(17)23-20(24-19)25-13-11-21-12-14-25/h2-10,15,21H,11-14H2,1H3,(H,22,23,24) |
| InChIKey | LOGWGZNWEWFTJV-UHFFFAOYSA-N |
| SMILES | CC(C1=CC=CC=C1)NC2=NC(=NC3=CC=CC=C32)N4CCNCC4 |
| Reference | [1]. Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. |
