For research use only. Not for therapeutic Use.
Daglutril (Cat.No:I006371), also known as SLV-306, is NEP/ECE inhibitor potentially for the treatment of hypertension, heart failure andpulmonary. SLV-306 (daglutril) inhibits systemic conversion of big endothelin-1 in humans.
| Catalog Number | I006371 |
| CAS Number | 182821-27-8 |
| Synonyms | Daglutril; SLV-306; SLV 306; SLV306.;((3S)-3-{1-((2R)-2-Ethoxycarbonyl-4-phenylbutyl)cyclopentanecarboxamido}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)acetic acid |
| Molecular Formula | C31H38N2O6 |
| Purity | ≥95% |
| Target | NEP/ECE inhibitor |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4°C for short term or -20 °C for long term |
| IUPAC Name | 2-[(3S)-3-[[1-[(2R)-2-ethoxycarbonyl-4-phenylbutyl]cyclopentanecarbonyl]amino]-2-oxo-4,5-dihydro-3H-1-benzazepin-1-yl]acetic acid |
| InChI | InChI=1S/C31H38N2O6/c1-2-39-29(37)24(15-14-22-10-4-3-5-11-22)20-31(18-8-9-19-31)30(38)32-25-17-16-23-12-6-7-13-26(23)33(28(25)36)21-27(34)35/h3-7,10-13,24-25H,2,8-9,14-21H2,1H3,(H,32,38)(H,34,35)/t24-,25+/m1/s1 |
| InChIKey | XMQODGUTLZXUGZ-RPBOFIJWSA-N |
| SMILES | CCOC(=O)C(CCC1=CC=CC=C1)CC2(CCCC2)C(=O)NC3CCC4=CC=CC=C4N(C3=O)CC(=O)O |
| Reference | </br>1:Effect on blood pressure of combined inhibition of endothelin-converting enzyme and neutral endopeptidase with daglutril in patients with type 2 diabetes who have albuminuria: a randomised, crossover, double-blind, placebo-controlled trial. Parvanova A, van der Meer IM, Iliev I, Perna A, Gaspari F, Trevisan R, Bossi A, Remuzzi G, Benigni A, Ruggenenti P; Daglutril in Diabetic Nephropathy Study Group..Lancet Diabetes Endocrinol. 2013 Sep;1(1):19-27. doi: 10.1016/S2213-8587(13)70029-9. Epub 2013 Jun 13. PMID: 24622263 </br>2:Daglutril for treatment of renal damage in hypertensive patients with type 2 diabetes: disappointment or hope? Laurent S.Lancet Diabetes Endocrinol. 2013 Sep;1(1):2-3. doi: 10.1016/S2213-8587(13)70036-6. Epub 2013 Jun 13. No abstract available. PMID: 24622251 </br>3:The dual endothelin converting enzyme/neutral endopeptidase inhibitor SLV-306 (daglutril), inhibits systemic conversion of big endothelin-1 in humans. Seed A, Kuc RE, Maguire JJ, Hillier C, Johnston F, Essers H, de Voogd HJ, McMurray J, Davenport AP.Life Sci. 2012 Oct 15;91(13-14):743-8. doi: 10.1016/j.lfs.2012.03.022. Epub 2012 Mar 28. PMID: 22480515 Free Article |
