Daltroban

• CAT Number: I017416
• CAS Number: 79094-20-5
• Molecular Formula: C₁₆H₁₆ClNO₄S
• Molecular Weight: 353.82
• Purity: ≥95%
• Target: Prostaglandin Receptor
• IUPAC Name: 2-[4-[2-[(4-chlorophenyl)sulfonylamino]ethyl]phenyl]acetic acid
• InChI: 1S/C16H16ClNO4S/c17-14-5-7-15(8-6-14)23(21,22)18-10-9-12-1-3-13(4-2-12)11-16(19)20/h1-8,18H,9-11H2,(H,19,20)
• InChIKey: IULOBWFWYDMECP-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1CCNS(=O)(=O)C2=CC=C(C=C2)Cl)CC(=O)O

Daltroban (Cat No.: I017416) is a selective thromboxane A2 (TXA2) receptor antagonist that inhibits platelet aggregation and vasoconstriction, making it a potential therapeutic agent for cardiovascular diseases. By blocking TXA2 receptors, Daltroban helps prevent thrombosis and improve blood flow, particularly in conditions like myocardial infarction and stroke. It also exhibits anti-inflammatory effects by modulating prostanoid pathways. Due to its targeted mechanism and vascular benefits, Daltroban is valuable in both experimental and clinical settings for investigating thrombotic and inflammatory vascular disorders.

Reference

[1]. Miki I, et al. Differences in activities of thromboxane A2 receptor antagonists in smooth muscle cells. Eur J Pharmacol. 1992 Oct 1;227(2):199-204.[2]. Thiemermann C, et al. The thromboxane receptor antagonist, daltroban, protects the myocardium from ischaemic injury resulting in suppression of leukocytosis. Eur J Pharmacol. 1988 Oct 11;155(1-2):57-67.[3]. Bhat AM, et al. Protective effect of the specific thromboxane receptor antagonist, BM-13505, in reperfusion injury following acute myocardial ischemia in cats. Am Heart J. 1989 Apr;117(4):799-803.