DAM-IN-1

• CAT Number: I040353
• CAS Number: 935279-95-1
• Molecular Formula: C16H17NO4
• Molecular Weight: 287.31
• Purity: ≥95%
• Synonyms: 4-ethoxycarbonyl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid
• InChI: InChI=1S/C16H17NO4/c1-2-21-16(20)14-11-5-3-4-10(11)12-8-9(15(18)19)6-7-13(12)17-14/h3-4,6-8,10-11,14,17H,2,5H2,1H3,(H,18,19)
• InChIKey: LQFSYWYGZHWLIW-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1C2CC=CC2C3=C(N1)C=CC(=C3)C(=O)O

DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor, IC50: 48 μM. DMA-IN-1 inhibits Caulobacter growth with an MIC of 35 μM[1].

Reference

[1]. Mashhoon N, et al. Selective inhibitors of bacterial DNA adenine methyltransferases. J Biomol Screen. 2006 Aug;11(5):497-510.
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