For research use only. Not for therapeutic Use.
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].
Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested (IC50=127 μM for KDM3A, or greater against other demethylases)[1].
Daminozide (200-20000 ppm) has teratogenic and genotoxic effects on model organism Drosophila melanogaster[2].
| CAS Number | 1596-84-5 |
| Synonyms | 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid |
| Molecular Formula | C6H12N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C6H12N2O3/c1-8(2)7-5(9)3-4-6(10)11/h3-4H2,1-2H3,(H,7,9)(H,10,11) |
| InChIKey | NOQGZXFMHARMLW-UHFFFAOYSA-N |
| SMILES | CN(C)NC(=O)CCC(=O)O |
| Reference | [1]. Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. [2]. Roy SS, et, al. Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism Drosophila melanogaster. Interdiscip Toxicol. 2018 May;11(1):27-37. |
