DAMPA

• CAT Number: R048569
• CAS Number: 19741-14-1
• Molecular Formula: C15H15N7O2
• Molecular Weight: 325.33
• Purity: ≥95%
• Synonyms: 4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoic Acid; 2,4-Diamino-N10-?methylpteroic Acid; 4-Amino-4-deoxy-10-methylpteroic Acid; 4-Amino-4-deoxy-N10-?methylpteroic Acid; 4-Amino-4-deoxy-N10-methylpteroic Acid; 4-Deoxy-4-amino-N10-?methylpte
• Storage: 2-8°C(protect from light)
• IUPAC Name: 4-[(2,4-diaminopteridin-6-yl)methyl-methylamino]benzoic acid
• InChI: InChI=1S/C15H15N7O2/c1-22(10-4-2-8(3-5-10)14(23)24)7-9-6-18-13-11(19-9)12(16)20-15(17)21-13/h2-6H,7H2,1H3,(H,23,24)(H4,16,17,18,20,21)
• InChIKey: LWCXZSDKANNOAR-UHFFFAOYSA-N
• SMILES: CN(CC1=CN=C2C(=N1)C(=NC(=N2)N)N)C3=CC=C(C=C3)C(=O)O

Methotrexate metabolite (DAMPA)（Cat No.:R048569）is the active metabolite of Methotrexate, a folic acid antagonist commonly used as an immunosuppressant. Methotrexate inhibits dihydrofolate reductase, leading to reduced folate levels and disrupting DNA synthesis and cell proliferation. As an immunosuppressant, it is prescribed to treat autoimmune diseases like rheumatoid arthritis, psoriasis, and inflammatory bowel disease. DAMPA is responsible for much of Methotrexate’s therapeutic effects, making it a crucial component in the mechanism of action of this widely used immunosuppressive medication.