Danofloxacin Mesylate

For research use only. Not for therapeutic Use.

  • CAT Number: A000878
  • CAS Number: 119478-55-6
  • Molecular Formula: C20H24FN3O6S
  • Molecular Weight: 453.48
  • Purity: ≥95%
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Danofloxacin mesylate(Cat No.:A000878)is a fluoroquinolone antibiotic used in veterinary medicine, particularly for treating respiratory infections in livestock such as cattle and swine. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for bacterial DNA replication and transcription, leading to bacterial cell death. Danofloxacin mesylate is effective against a range of gram-negative and gram-positive pathogens, making it valuable for controlling respiratory diseases caused by bacteria like Mannheimia haemolytica and Pasteurella multocida. Its strong efficacy and rapid action support animal health and help reduce the spread of infections in agricultural settings.


Catalog Number A000878
CAS Number 119478-55-6
Synonyms

Danofloxacin mesylate; 119478-55-6; Advocin; Danofloxacin (mesylate); UNII-94F3SX3LEM; DANOFLOXACIN MESILATE

Molecular Formula C20H24FN3O6S
Purity ≥95%
Target Bacterial
Storage -20°C
IUPAC Name 1-cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]-4-oxoquinoline-3-carboxylic acid;methanesulfonic acid
InChI InChI=1S/C19H20FN3O3.CH4O3S/c1-21-7-12-4-11(21)8-22(12)17-6-16-13(5-15(17)20)18(24)14(19(25)26)9-23(16)10-2-3-10;1-5(2,3)4/h5-6,9-12H,2-4,7-8H2,1H3,(H,25,26);1H3,(H,2,3,4)/t11-,12-;/m0./s1
InChIKey APFDJSVKQNSTKF-FXMYHANSSA-N
SMILES CN1C[C@@H]2C[C@H]1CN2C3=C(C=C4C(=C3)N(C=C(C4=O)C(=O)O)C5CC5)F.CS(=O)(=O)O
Reference

1: Wang C, Ai D, Chen C, Lin H, Li J, Shen H, Yi W, Qi Y, Wu H, Cao J.
Preparation and evaluation of danofloxacin mesylate microspheres and its
pharmacokinetics in pigs. Vet Res Commun. 2009 Dec;33(8):1013-22. doi:
10.1007/s11259-009-9320-6. Epub 2009 Sep 23. PubMed PMID: 19774478.

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2: Schrickx JA, Fink-Gremmels J. Danofloxacin-mesylate is a substrate for
ATP-dependent efflux transporters. Br J Pharmacol. 2007 Feb;150(4):463-9. Epub
2007 Jan 8. PubMed PMID: 17211460; PubMed Central PMCID: PMC2189727.

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