For research use only. Not for therapeutic Use.
Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.
Dansyl glutathione is used as a trapping agent to aid the quantitation of adducts following in vitro incubation of drugs with human liver microsomes in the presence and absence of NADPH[1].
| Catalog Number | I019928 |
| CAS Number | 75017-02-6 |
| Synonyms | (2S)-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-2-[[5-(dimethylamino)naphthalen-1-yl]sulfonylamino]-5-oxopentanoic acid |
| Molecular Formula | C22H28N4O8S2 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H28N4O8S2/c1-26(2)17-7-3-6-14-13(17)5-4-8-18(14)36(33,34)25-15(22(31)32)9-10-19(27)24-16(12-35)21(30)23-11-20(28)29/h3-8,15-16,25,35H,9-12H2,1-2H3,(H,23,30)(H,24,27)(H,28,29)(H,31,32)/t15-,16-/m0/s1 |
| InChIKey | FFXGOBFBYCOXAJ-HOTGVXAUSA-N |
| SMILES | CN(C)C1=CC=CC2=C1C=CC=C2S(=O)(=O)NC(CCC(=O)NC(CS)C(=O)NCC(=O)O)C(=O)O |
| Reference | [1]. Gan J, et al. In vitro screening of 50 highly prescribed drugs for thiol adduct formation–comparison of potential for drug-induced toxicity and extent of adduct formation. Chem Res Toxicol. 2009 Apr;22(4):690-8. |
