For research use only. Not for therapeutic Use.
<p>As a blocker of Ca<sup>2+</sup> release from sarcoplasmic reticulum it is a skeletal muscle relaxant.</p><br />Hydantoin derivative,<!–C<SUB>14</SUB>H<SUB>9</SUB>N<SUB>4</SUB>NaO<SUB>5</SUB>–>synthetic.</br><p>It selectively inhibits the Ca-induced Ca<sup>2+</sup> release mechanism from sarcoplasmic reticulum in guinea pig skeletal muscle, only at physiological temperature (38 °C), under various conditions. (50 &mu;M at low temperature (20 °C) does not inhibit this mechanism).</p></br>
| Catalog Number | R043598 |
| CAS Number | 7261-97-4 |
| Synonyms | 1-[[5-(p-Nitrophenyl)furfurylidene]amino]hydantoin; 1-[[5-(p-Nitrophenyl)furfurylidene]amino]hydantoin; F 368; |
| Molecular Formula | C14H10N4O5 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| IUPAC Name | 1-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]imidazolidine-2,4-dione |
| InChI | InChI=1S/C14H10N4O5/c19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22/h1-7H,8H2,(H,16,19,20)/b15-7+ |
| InChIKey | OZOMQRBLCMDCEG-VIZOYTHASA-N |
| SMILES | C1C(=O)NC(=O)N1N=CC2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-] |
| Reference | </br>1:Mind the magnesium, in dantrolene suppression of malignant hyperthermia. Cannon SC.Proc Natl Acad Sci U S A. 2017 May 2;114(18):4576-4578. doi: 10.1073/pnas.1704103114. Epub 2017 Apr 25. No abstract available. PMID: 28442565 </br>2:Dantrolene requires Mg<sup>2+</sup> to arrest malignant hyperthermia. Choi RH, Koenig X, Launikonis BS.Proc Natl Acad Sci U S A. 2017 May 2;114(18):4811-4815. doi: 10.1073/pnas.1619835114. Epub 2017 Apr 3. PMID: 28373535 </br>3:Treatment of Malignant Hyperthermia without Dantrolene in a 14-year-old Boy. Liu ST, Liu LF, Wang SY.Chin Med J (Engl). 2017 Mar 20;130(6):755-756. doi: 10.4103/0366-6999.201616. No abstract available. PMID: 28303866 Free PMC Article</br>4:Early Development, Identification of Mode of Action, and Use of Dantrolene Sodium: The Role of Keith Ellis, Ph.D. Pollock NA, Machon RG, Rosenberg H.Anesthesiology. 2017 May;126(5):774-779. doi: 10.1097/ALN.0000000000001596. PMID: 28272142 </br>5:A case of rapid progression of postoperative hyperthermia: Dantrolene or not dilemma? Honardar MR, Rubio J, Bhananker SM.Int J Crit Illn Inj Sci. 2016 Oct-Dec;6(4):203-205. doi: 10.4103/2229-5151.195451. PMID: 28149827 Free PMC Article</br>6:Dantrolene versus amiodarone for cardiopulmonary resuscitation: a randomized, double-blinded experimental study. Wiesmann T, Freitag D, Dersch W, Eschbach D, Irqsusi M, Steinfeldt T, Wulf H, Feldmann C.Sci Rep. 2017 Jan 18;7:40875. doi: 10.1038/srep40875. PMID: 28098197 Free PMC Article</br>7:Preparation, characterization and in vivo evaluation of a formulation of dantrolene sodium with hydroxypropyl-β-cyclodextrin. Chen M, Wu Q, Jiang J, Jin X, Liu S, Wang M, Zhao C.J Pharm Biomed Anal. 2017 Feb 20;135:153-159. doi: 10.1016/j.jpba.2016.12.022. Epub 2016 Dec 19. PMID: 28027523 </br>8:Erratum to: Counter-flow suggests transport of dantrolene and 5-OH dantrolene by the organic anion transporters 2 (OAT2) and 3 (OAT3). Burckhardt BC, Henjakovic M, Hagos Y, Burckhardt G.Pflugers Arch. 2016 Nov;468(11-12):1919-1920. No abstract available. PMID: 27889824 </br>9:Long term oral Dantrolene Improved Muscular Symptoms in a Malignant Hyperthermia Susceptible Individual. Butala BN, Kang A, Guron J, Brandom BW.J Neuromuscul Dis. 2016 Mar 3;3(1):115-119. PMID: 27854207 </br>10:Dantrolene: A Selective Ryanodine Receptor Antagonist, Protects Against Pentylenetetrazole-Induced Seizure in Mice. Keshavarz M, Fotouhi M, Rasti A.Acta Med Iran. 2016 Sep;54(9):555-561. PMID: 27832686 Free Article |
