For research use only. Not for therapeutic Use.
Daphnetin, a natural coumarin derivative, is a protein kinase inhibitor, inhibits EGFR, PKA and PKC with IC50 of 7.67 μM, 9.33 μM and 25.01 μM, respectively, also known to exhibit anti-inflammatory and anti-oxidant activities.<br>Daphnetin strongly inhibits not only EGF receptor-catalyzed tyrosine phosphorylation of exogenous substrate but also PKA and PKC activities.<br>Daphnetin at 140 mg/kg significantly decreases uterine weights by 39.5%.
| Catalog Number | I006687 |
| CAS Number | 486-35-1 |
| Molecular Formula | C9H6O4 |
| Purity | ≥95% |
| Target | EGFR |
| Storage | 3 years -20C powder |
| IUPAC Name | 7,8-dihydroxychromen-2-one |
| InChI | InChI=1S/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H |
| InChIKey | ATEFPOUAMCWAQS-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C2=C1C=CC(=O)O2)O)O |
