Dapson

• CAT Number: A000054
• CAS Number: 80-08-0
• Molecular Formula: C12H12N2O2S
• Molecular Weight: 248.30
• Purity: ≥95%
• Synonyms: Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS
• Target: NF-κB
• Storage: Store at -20°C
• IUPAC Name: 4-(4-aminophenyl)sulfonylaniline
• InChI: InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
• InChIKey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N

Dapsone（Cat No.:A000054）is an antimicrobial and anti-inflammatory compound widely used in the treatment of infectious and autoimmune diseases. As a sulfone antibiotic, it inhibits dihydropteroate synthase, a key enzyme in folate synthesis, making it effective against Mycobacterium leprae and Pneumocystis jirovecii. Dapsone is a cornerstone in managing leprosy, often in combination therapy, and is also used for dermatitis herpetiformis, a skin condition associated with celiac disease. Additionally, it exhibits anti-inflammatory properties, making it valuable in treating autoimmune blistering diseases. Its versatility underscores its importance in dermatological and infectious disease research.

Reference

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