Dapson

• CAT Number: A000054
• CAS Number: 80-08-0
• Molecular Formula: C12H12N2O2S
• Molecular Weight: 248.3
• Purity: ≥95%
• Synonyms: Dapsone, 4,4′-Diaminodiphenyl sulfone, 4,4′-Sulfonyldianiline, 4-Aminophenyl sulfone, Bis(4-aminophenyl) sulfone, DDS
• Storage: Store at -20°C
• InChI: 1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
• InChIKey: MQJKPEGWNLWLTK-UHFFFAOYSA-N
• SMILES: C1=CC(=CC=C1N)S(=O)(=O)C2=CC=C(C=C2)N

Dapsone is a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties, commonly used for the treatment of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Dapsone is available both topically and by mouth. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis.

Reference

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