DAPT

• CAT Number: A000703
• CAS Number: 208255-80-5
• Molecular Formula: C₂₃H₂₆F₂N₂O₄
• Molecular Weight: 432.46
• Purity: ≥95%
• Synonyms: LY-374973
• Target: Amyloid β
• Solubility: >21.6mg/mL in DMSO
• Storage: 3 years -20C powder
• InChI: InChI=1S/C23H26F2N2O4/c1-14(26-19(28)12-15-10-17(24)13-18(25)11-15)21(29)27-20(16-8-6-5-7-9-16)22(30)31-23(2,3)4/h5-11,13-14,20H,12H2,1-4H3,(H,26,28)(H,27,29)/t14-,20-/m0/s1
• InChIKey: DWJXYEABWRJFSP-XOBRGWDASA-N
• SMILES: CC(C(=O)NC(C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F

DAPT, also known GSI-IX, is a potent and selective γ-secretase inhibitor. DAPT is a non-transition-state analogue GSI and is the compound most widely evaluated in experimental models. DAPT causes a reduction in Aβ levels in human primary neuronal cell cultures with IC50 values = 115−200 nM. DAPT blocks Notch signaling in a cell-based assay measuring the activation of the Notch pathway reporter gene with an IC50 = 500 nM. As an inhibitor of Notch, DAPT has also been used in the study of autoimmune and lymphoproliferative diseases.

Reference

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