Daptomycin

For research use only. Not for therapeutic Use.

  • CAT Number: A000562
  • CAS Number: 103060-53-3
  • Molecular Formula: C72H101N17O26
  • Molecular Weight: 1620.70
  • Purity: ≥95%
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Daptomycin(Cat No.:A000562)is a cyclic lipopeptide antibiotic used to treat serious bacterial infections, including complicated skin infections and bloodstream infections caused by Gram-positive organisms like Staphylococcus aureus and Enterococcus species. It works by binding to bacterial cell membranes and disrupting essential ion gradients, leading to rapid cell death. Unlike many antibiotics, daptomycin maintains efficacy against resistant strains, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Known for its potency and unique mechanism, daptomycin is valuable in managing multidrug-resistant infections in hospital settings, supporting effective patient outcomes in difficult-to-treat cases.


Catalog Number A000562
CAS Number 103060-53-3
Synonyms

DAPTOMYCIN; Cubicin; 103060-53-3; Cidecin

Molecular Formula C72H101N17O26
Purity ≥95%
Target DNA Synthesis
Solubility >81.1mg/mL in DMSO
Storage -20°C
Reference

1: Kato H, Hagihara M, Murakami E, Suematsu H, Nishiyama N, Koizumi Y, Yamagishi
Y, Uno B, Mikamo H. Considerations about the Use of a Loading Dose of Daptomycin
in a Neutropenic Murine Thigh Infection Model with Methicillin-Resistant
Staphylococcus aureus Infection. Chemotherapy. 2017 Nov 11;63(1):13-19. doi:
10.1159/000481158. [Epub ahead of print] PubMed PMID: 29130946.
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2: Kreutzberger MA, Pokorny A, Almeida PF. Daptomycin-Phosphatidylglycerol
Domains in Lipid Membranes. Langmuir. 2017 Nov 13. doi:
10.1021/acs.langmuir.7b01841. [Epub ahead of print] PubMed PMID: 29130685.

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3: Belley A, Arhin FA, Moeck G. Evaluation of Oritavancin Dosing Strategies
against Vancomycin-Resistant Enterococcus faecium Isolates with or without
Reduced Susceptibility to Daptomycin in an in vitro
Pharmacokinetic/Pharmacodynamic Model. Antimicrob Agents Chemother. 2017 Nov 6.
pii: AAC.01873-17. doi: 10.1128/AAC.01873-17. [Epub ahead of print] PubMed PMID:
29109163.
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4: Higashi Y, Nakamura S, Tsuji Y, Ogami C, Matsumoto K, Kawago K, Tokui K,
Hayashi R, Sakamaki I, Yamamoto Y. A Case of Daptomycin-induced Eosinophilic
Pneumonia and a Review of the Published Literature. Intern Med. 2017 Nov 1. doi:
10.2169/internalmedicine.9010-17. [Epub ahead of print] PubMed PMID: 29093391.
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5: Gómez Casanova N, Siller Ruiz M, Mu&#241;oz Bellido JL. Mechanisms of resistance to
daptomycin in Staphylococcus aureus. Rev Esp Quimioter. 2017 Oct 25. pii:
gomez25oct2017. [Epub ahead of print] Review. PubMed PMID: 29082727.
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6: Heidary M, Khosravi AD, Khoshnood S, Nasiri MJ, Soleimani S, Goudarzi M.
Daptomycin. J Antimicrob Chemother. 2017 Oct 20. doi: 10.1093/jac/dkx349. [Epub
ahead of print] PubMed PMID: 29059358.
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7: Taylor R, Beriashvili D, Taylor S, Palmer M. Daptomycin Pore Formation Is
Restricted by Lipid Acyl Chain Composition. ACS Infect Dis. 2017 Nov
10;3(11):797-801. doi: 10.1021/acsinfecdis.7b00138. Epub 2017 Oct 23. PubMed
PMID: 29048870.

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8: Mao XM, Luo S, Li YQ. Negative regulation of daptomycin production by DepR2,
an ArsR-family transcriptional factor. J Ind Microbiol Biotechnol. 2017
Dec;44(12):1653-1658. doi: 10.1007/s10295-017-1983-3. Epub 2017 Oct 16. PubMed
PMID: 29038911.
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9: Bhardwaj P, Hans A, Ruikar K, Guan Z, Palmer KL. Reduced chlorhexidine and
daptomycin susceptibility in vancomycin-resistant Enterococcus faecium after
serial chlorhexidine exposure. Antimicrob Agents Chemother. 2017 Oct 16. pii:
AAC.01235-17. doi: 10.1128/AAC.01235-17. [Epub ahead of print] PubMed PMID:
29038276.
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10: Chanderraj R, Banerjee M, Rao K. High-Dose Daptomycin and Mortality: The Case
Is Not Yet Closed. Clin Infect Dis. 2017 Oct 15;65(8):1426-1427. doi:
10.1093/cid/cix551. PubMed PMID: 29017242.

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