Darinaparsin

• CAT Number: R015179
• CAS Number: 69819-86-9
• Molecular Formula: C12H22AsN3O6S
• Molecular Weight: 411.30
• Purity: ≥95%
• Synonyms: N-[S-(Dimethylarsino)-N-L-γ-glutamyl-L-cysteinyl]-glycine; Dimethylarsinic Glutathione; ZIO 101; Zinapar; L-γ-Glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine
• Target: Apoptosis
• Storage: -20°C
• IUPAC Name: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-dimethylarsanylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• InChI: InChI=1S/C12H22AsN3O6S/c1-13(2)23-6-8(11(20)15-5-10(18)19)16-9(17)4-3-7(14)12(21)22/h7-8H,3-6,14H2,1-2H3,(H,15,20)(H,16,17)(H,18,19)(H,21,22)/t7-,8-/m0/s1
• InChIKey: JGDXFQORBMPJGR-YUMQZZPRSA-N
• SMILES: C[As](C)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N

Darinaparsin(CAT: R015179) is an organoarsenic compound used as an anticancer agent, particularly in the treatment of hematologic malignancies such as peripheral T-cell lymphoma. Its mechanism of action involves inducing oxidative stress, disrupting mitochondrial function, and promoting apoptosis in cancer cells. Unlike traditional arsenic trioxide therapies, darinaparsin has a modified chemical structure that enhances its therapeutic index and reduces toxicity. This compound is being explored in clinical trials for its efficacy against various cancers, and its unique action on cellular redox systems makes it a valuable agent in oncological research and drug development.