For research use only. Not for therapeutic Use.
DAS-5-oCRBN (Cat No.: I040131) is a small-molecule compound that functions as a ligand for cereblon (CRBN), a protein involved in regulating the ubiquitin-proteasome system. By binding to CRBN, DAS-5-oCRBN can modulate protein degradation pathways, which are critical for controlling cellular processes like growth, differentiation, and survival. It has potential applications in cancer therapy, particularly in the context of targeted protein degradation strategies. DAS-5-oCRBN may enhance the efficacy of immunomodulatory drugs and offer a novel approach to treating hematological malignancies or other diseases.
| Synonyms | N-(2-chloro-6-methylphenyl)-2-[[6-[4-[2-[4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]piperazin-1-yl]-2-oxoethyl]piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-1,3-thiazole-5-carboxamide |
| Molecular Formula | C39H40ClN11O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C39H40ClN11O6S/c1-22-5-3-7-25(40)34(22)46-36(55)28-20-41-39(58-28)44-29-19-30(43-23(2)42-29)49-13-11-47(12-14-49)21-32(53)50-17-15-48(16-18-50)26-8-4-6-24-33(26)38(57)51(37(24)56)27-9-10-31(52)45-35(27)54/h3-8,19-20,27H,9-18,21H2,1-2H3,(H,46,55)(H,45,52,54)(H,41,42,43,44) |
| InChIKey | FLJSWUPMVJVFTN-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=CC(=NC(=N3)C)N4CCN(CC4)CC(=O)N5CCN(CC5)C6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O |
| Reference | [1]. Mao W, et al. Selective and Potent PROTAC Degraders of c-Src Kinase. ACS Chem Biol. 2024 Jan 19;19(1):110-116. |
