For research use only. Not for therapeutic Use.
Dasabuvir（Cat No.:I000498）is a non-nucleoside inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase, NS5B. By binding to an allosteric site on NS5B, it disrupts viral RNA replication, making it a critical component in combination therapies for chronic HCV infection. Dasabuvir is effective against multiple HCV genotypes and is commonly used alongside other direct-acting antivirals to enhance treatment efficacy and reduce resistance. Its favorable pharmacokinetics and high specificity contribute to improved sustained virologic response rates, aiding in the management and potential eradication of HCV.
| Catalog Number | I000498 |
| CAS Number | 1132935-63-7 |
| Synonyms | ABT333; ABT-333; ABT 333 |
| Molecular Formula | C26H27N3O5S |
| Purity | ≥95% |
| Target | Cell Cycle/DNA Damage |
| Solubility | DMSO: ≥ 46 mg/mL |
| Storage | Store at -20°C |
| IUPAC Name | N-[6-[3-tert-butyl-5-(2,4-dioxopyrimidin-1-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide |
| InChI | InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31) |
| InChIKey | NBRBXGKOEOGLOI-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O |
| Reference | 1: King JR, Zha J, Khatri A, Dutta S, Menon RM. Clinical Pharmacokinetics of 2: Mantry PS, Pathak L. Dasabuvir (ABT333) for the treatment of chronic HCV <br> <br> <br> |
