Daunomycinone

• CAT Number: R004502
• CAS Number: 21794-55-8
• Molecular Formula: C21H18O8
• Molecular Weight: 398.367
• Purity: ≥95%
• Synonyms: (8S,10S)-8-Acetyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy- -5,12-naphthacenedione; (+)-Daunomycinone; Daunomycin Aglicone; Daunomycinon; Daunorubicin Aglycone; Daunorubicinone; Leukaemomycinone C; NSC 109351
• Storage: Desiccate at RT
• IUPAC Name: (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
• InChI: InChI=1S/C21H18O8/c1-8(22)21(28)6-10-13(11(23)7-21)19(26)16-15(18(10)25)17(24)9-4-3-5-12(29-2)14(9)20(16)27/h3-5,11,23,25-26,28H,6-7H2,1-2H3/t11-,21-/m0/s1
• InChIKey: YOFDHOWPGULAQF-MQJDWESPSA-N
• SMILES: CC(=O)C1(CC(C2=C(C3=C(C(=C2C1)O)C(=O)C4=C(C3=O)C(=CC=C4)OC)O)O)O

Daunomycinone is a key anthracycline aglycone and the active metabolite of the chemotherapeutic agent daunorubicin. It is widely used in cancer research for studying its mechanisms of action and its effects on DNA synthesis and repair. This compound’s high purity ensures consistent and reliable results in experimental settings. Daunomycinone is essential for developing new anticancer therapies and understanding drug resistance mechanisms. Its applications extend to biochemical and pharmacological studies, making it a vital tool in advanced cancer research.