For research use only. Not for therapeutic Use.
Daunorubicin hydrochloride（Cat No.:A000963）is an anthracycline chemotherapy agent used primarily in the treatment of acute leukemia, including acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL). It works by intercalating into DNA, disrupting replication and transcription, and generating reactive oxygen species that lead to apoptosis in rapidly dividing cancer cells. Daunorubicin’s effectiveness is often enhanced when used in combination with other chemotherapeutic agents. While it is effective against various hematological malignancies, its use is associated with potential side effects, including cardiotoxicity, necessitating careful monitoring during treatment. Ongoing research continues to explore its applications and combination strategies.
| Catalog Number | A000963 |
| CAS Number | 23541-50-6 |
| Synonyms | Daunomycin HCl |
| Molecular Formula | C27H29NO10 • HCl |
| Purity | ≥95% |
| Target | Antibody-drug Conjugate/ADC Related |
| Solubility | >28.2mg/mL in DMSO |
| Storage | 3 years -20C powder |
| Reference | <p>Mizuno, N.S., et al., Binding of daunomycin to DNA and the inhibition of RNA and DNA synthesis. <em>Cancer Res.</em> <strong>35</strong>, 1542-1546, (1975)</p> |
