DAVP-1

For research use only. Not for therapeutic Use.

  • CAT Number: I025557
  • Purity: 98%
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DAVP-1 (Cat No.: I025557) is a synthetic analog of vasopressin, designed to selectively activate vasopressin V2 receptors. It is primarily used in research to study water reabsorption mechanisms in the kidneys and to explore treatments for conditions like diabetes insipidus and hyponatremia. By stimulating V2 receptors, DAVP-1 promotes the insertion of aquaporin-2 channels into renal tubules, enhancing water retention. Its receptor selectivity and stability make it a valuable tool for dissecting vasopressin signaling pathways and evaluating potential therapeutic strategies targeting water balance disorders.


Synonyms

DAVP-1; DAVP 1; DAVP1;

Purity 98%
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 4-dimethylamino-6-vinylpyrimidine
InChI InChI=1S/C8H11N3/c1-4-7-5-8(11(2)3)10-6-9-7/h4-6H,1H2,2-3H3
InChIKey GFZDHKFQHAEMGL-UHFFFAOYSA-N
SMILES C=CC1=CC(N(C)C)=NC=N1
Reference

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mechanistically distinct inhibitors of HIV-1 reverse transcriptase through
fragment screening. Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6979-84. doi:
10.1073/pnas.1423900112. Epub 2015 May 18. PubMed PMID: 26038551; PubMed Central
PMCID: PMC4460473.
2: Bellucci L, Angeli L, Tafi A, Radi M, Botta M. Unconventional plasticity of
HIV-1 reverse transcriptase: how inhibitors could open a connection “gate”
between allosteric and catalytic sites. J Chem Inf Model. 2013 Dec
23;53(12):3117-22. doi: 10.1021/ci400414s. Epub 2013 Nov 25. PubMed PMID:
24256065.
3: Freisz S, Bec G, Radi M, Wolff P, Crespan E, Angeli L, Dumas P, Maga G, Botta
M, Ennifar E. Crystal structure of HIV-1 reverse transcriptase bound to a
non-nucleoside inhibitor with a novel mechanism of action. Angew Chem Int Ed
Engl. 2010 Mar 1;49(10):1805-8. doi: 10.1002/anie.200905651. PubMed PMID:
20135654.
4: Guillon G, Pena A, Murat B, Derick S, Trueba M, Ventura MA, Szeto HH, Wo N,
Stoev S, Cheng LL, Manning M. Position 4 analogues of [deamino-Cys(1)] arginine
vasopressin exhibit striking species differences for human and rat V(2)/V(1b)
receptor selectivity. J Pept Sci. 2006 Mar;12(3):190-8. PubMed PMID: 16130178.
5: Lammek B, Bankowski K, Misicka A, Manning M, Seto J, Sawyer WH.
2-O-alkyltyrosine derivatives of 1-deamino-arginine-vasopressin: highly specific
and potent antidiuretic agonists. J Med Chem. 1989 Jan;32(1):244-7. PubMed PMID:
2909737.

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