Dazopride fumarate

• CAT Number: I025564
• CAS Number: 81957-25-7
• Molecular Formula: C19H27ClN4O6
• Molecular Weight: 442.89
• Purity: 98%
• Synonyms: AHR-5531C, Dazopride fumarate
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Benzamide, 4-amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxy-, (E)-2-butenedioate (1:1)
• InChI: 1S/C15H23ClN4O2.C4H4O4/c1-4-19-8-10(9-20(19)5-2)18-15(21)11-6-12(16)13(17)7-14(11)22-3;5-3(6)1-2-4(7)8/h6-7,10H,4-5,8-9,17H2,1-3H3,(H,18,21);1-2H,(H,5,6)(H,7,8)/b;2-1+
• InChIKey: IGGKTAIAQUIFKQ-WLHGVMLRSA-N
• SMILES: CCN1CC(CN1CC)NC(=O)c2cc(Cl)c(N)cc2OC.OC(=O)C=CC(=O)O

Dazopride fumarate is a peristaltic used to enhance gastric emptying and block emesis.

Reference

1: Grant SC, Kris MG, Gralla RJ, Clark RA, Tyson LB. Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy. Cancer Chemother Pharmacol. 1993;31(6):442-4. PubMed PMID: 8453682.
2: Costall B, Domeney AM, Gunning SJ, Kelly ME, Naylor RJ, Nohria V, Owera-Atepo JB, Simpson KM, Tan CC, Tattersall D. The action of dazopride to enhance gastric emptying and block emesis. Neuropharmacology. 1987 Jul;26(7A):669-77. PubMed PMID: 3114664.
3: Alphin RS, Proakis AG, Leonard CA, Smith WL, Dannenburg WN, Kinnier WJ, Johnson DN, Sancilio LF, Ward JW. Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility. Dig Dis Sci. 1986 May;31(5):524-9. PubMed PMID: 3698769.